• Tips gratefully accepted here. Thanks!:

  • Recent Comments

    William on This part is interesting…
    Ivory Bill Woodpecke… on This part is interesting…
    Ivory Bill Woodpecke… on I’d hate to be this DOJ lawyer…
    Ivory Bill Woodpecke… on I’d hate to be this DOJ lawyer…
    Ivory Bill Woodpecke… on I’d hate to be this DOJ lawyer…
    Niles on I’d hate to be this DOJ lawyer…
    Ivory Bill Woodpecke… on This part is interesting…
    Ivory Bill Woodpecke… on I’d hate to be this DOJ lawyer…
    Ivory Bill Woodpecke… on I’d hate to be this DOJ lawyer…
    Ivory Bill Woodpecke… on I’d hate to be this DOJ lawyer…
    tamens on I’d hate to be this DOJ lawyer…
    Sweet Sue on This part is interesting…
    riverdaughter on This part is interesting…
    riverdaughter on I’d hate to be this DOJ lawyer…
    Niles on I’d hate to be this DOJ lawyer…
  • Categories


  • Tags

    abortion Add new tag Afghanistan Al Franken Anglachel Atrios bankers Barack Obama Bernie Sanders big pharma Bill Clinton cocktails Conflucians Say Dailykos Democratic Party Democrats Digby DNC Donald Trump Donna Brazile Economy Elizabeth Warren feminism Florida Fox News General Glenn Beck Glenn Greenwald Goldman Sachs health care Health Care Reform Hillary Clinton Howard Dean John Edwards John McCain Jon Corzine Karl Rove Matt Taibbi Media medicare Michelle Obama Michigan misogyny Mitt Romney Morning Edition Morning News Links Nancy Pelosi New Jersey news NO WE WON'T Obama Obamacare OccupyWallStreet occupy wall street Open thread Paul Krugman Politics Presidential Election 2008 PUMA racism Republicans research Sarah Palin sexism Single Payer snark Social Security Supreme Court Terry Gross Texas Tim Geithner unemployment Wall Street WikiLeaks women
  • Archives

  • History

    May 2013
    S M T W T F S
    « Apr   Jun »
     1234
    567891011
    12131415161718
    19202122232425
    262728293031  
  • RSS Paul Krugman: Conscience of a Liberal

  • The Confluence

    The Confluence

  • RSS Suburban Guerrilla

  • RSS Ian Welsh

    • Fundraising Update and the Art Of Thinking
      We have raised $9,353. That means we’ve reached the first two milestones, and I’ll write sixteen reviews of books with useful information. The final milestone is at $11,000, and is to be a booklet, “How To Think: Understanding the World.” The fundraiser will end at midnight this coming Friday, June 28th. DONATE OR SUBSCRIBE I […]
  • Top Posts

  • Advertisements

Calling all medicinal chemists, time to contact Virtually Speaking

I was mulching my flower beds, listening to the latest Virtually Speaking with Dean Baker and Jay Ackroyd when I heard the same moronic bullshit about how drugs are REALLY all discovered in academic labs using government money and the drug companies just put the finishing touches on them, develop them and charge a small fortune.

I’ll give you the fortune bit, for sure.  There’s no doubt that the marketers and finance guys are charging what the market will bear and then some.  They’re greedy, ruthless and cruel.  The whole drug industry has pivoted to serve the owners and the owners want money.  That affects what gets researched, promoted and sold and at what cost.

BUT

There is absolutely no truth to the idea that academia passes on almost fully formed drugs to industry where we researchers add our special sauce flourishes and then cash in big.

I repeat.

There is absolutely no truth to the idea that academia passes on almost fully formed drugs to industry where we researchers add our special sauce flourishes and then cash in big.

If Dean Baker and Jay Ackroyd and Yves Smith want to propagate this myth, they can knock themselves out.  But it’s no more true that the idea that Bill and Hillary Clinton did something nefarious with a land deal in the Ozarks.

Maybe it’s what they want to be true, maybe it fits their worldview, maybe it’s wishful thinking but it not true.  And I should know because I’ve worked in both industrial and academic settings and I actually DO the kind of drug discovery that Jay and Dean talk about so confidently but have no clue about.

The truth is that academia rarely submits a fully realized drug entity to industry for development.  What it submits is frequently just an idea.  Sometimes, that is just a target (a protein, receptor, gene, etc) and sometimes, it consists of some very basic building blocks.  Those building blocks will not resemble the final drug product until industrial medicinal chemists spend years and years rescaffolding it, making new appendages for it, and developing whole libraries of potential drug compounds that may not resemble the initial compound in the least when they are finished.

So, yes, the NIH funds a lot of research but, no, that research does not result in anywhere near effective or consumable drugs until industrial chemists get their hands on it and bend it to their wills.  By the way, those industrial chemists used to be academic chemists.  It’s not supposed to be an adversarial relationship.

Anyway, for all you pharma researchers out there who are pissed off by the “everybody knows” truthiness and yet more dissing of your shrinking profession and want to set the record straight, let Jay Ackroyd at Virtually Speaking know.  God only knows why Jay won’t simply invite someone like Derek Lowe on his show to tell it like it really is.  It’s almost like they don’t want to hear the truth, that somehow by sticking their fingers in their ears and singing “la-la-la, I can’t HEAR you”, that that’s going to make the poor graduate students working for peanuts into unsung heroes and pump lots of righteous indignation into the put upon American people.  Well, those graduate students ARE unsung heroes, but so are many of my former industrial colleagues in medicinal chemistry and drug design who have slaved tirelessly for years wrestling some academic’s decidedly un-druglike molecule into a real drug that can be developed.

I’m really insulted by this poor performance by Ackroyd and Baker.  The left deserves people who are not lazy and who will actually go out of their way to get to the truth.  Otherwise, the drug industry will continue to fail, drugs will continue to skyrocket in price and no one will be able to do anything about it because they’ll all be off chasing wild geese or red herrings or whatever it is you call it that is just a waste of time and energy.

Jay and Dean aren’t even seeing through a glass darkly at this point.  If they would only come and actually, you know, talk to us, we could tell them what’s really going on so they could talk more intelligently about a subject they clearly know nothing about at the present time.  I’m not sure what is holding them back.  Is it the absurd notion that those of us who work(ed) for industry  are as greedy, ruthless and conservative as the guys who laid us all off?  Even if that were true, (it’s not, not by a long shot) is that a good reason for ignoring what we have to say?

You can’t fix a problem if you are totally ignorant.

Here’s Jay’s links if you want to set the record straight.

Jay on Facebook

Jay on Twitter

VS Guests on Twitter

VS in Second Life

VS Ning

VS on BlogTalkRadio

VS on Facebook

VS on Itunes

And here is Dean Baker’s twitter feed.

 

 

 

 

Advertisements

Voglio Una Casa

Google Translation:

I want a house, I want beautiful
Full of light like a star
Sunny and luck
And the moon over the roof cues
Full of laughter, full of tears
House you dream, you dream so
Dididindi, Dididindi …

I want a home, for many people
I want solid and comfortable,
Rugged and warm, simple and true
To get music morning and evening
And the poem has its bed
I want to live under that roof.
Dididindi, Dididindi …

I want every home, which is inhabited
And no one sleeps on the street
Like a dog to beg
Why has no where to go
Treated like a beast spitting
And nobody, no one will help him.
Dididindi, Dididindi …

I want a home for boys,
who never know where to meet
and for the old, spacious homes
that they can live with relatives
houses do not care, for families
and that we are born sons and daughters.
Dididindi, Dididindi …